Advances in cancer screenings have significantly increased survival rates, allowing people to live longer after a diagnosis. Routine screenings catch cancer in its early stages when treatment is more effective, but experts caution that certain symptoms, like unexplained weight loss and persistent fatigue, should never be ignored.

Although experiencing one or more of these symptoms doesn’t necessarily mean cancer, addressing them with your doctor is essential. Here are five critical signs that warrant further medical attention.

Unexplained weight loss and fatigue: red flags for early detection

One of the most common early warning signs is unexplained weight loss. Losing more than 10 pounds without any changes to your diet or exercise routine could be an early indication of cancer, particularly in cases of gastrointestinal or pancreatic cancer. While many instances of weight loss may have benign causes, it’s important to consult your physician to rule out any serious underlying conditions.

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Another common but often overlooked symptom is extreme fatigue. Unlike everyday tiredness, this type of exhaustion persists despite rest and could signal the body’s struggle as cancer cells use nutrients to grow. Known as “nutrient theft,” cancer can drain the body of vital energy, leading to chronic fatigue that severely impacts daily life.

Other symptoms: fever, pain, and skin changes could signal an issue

Fever is typically associated with infections such as the flu, but recurring, unexplained fevers — particularly those that occur mainly at night or are accompanied by night sweats — can be an early sign of cancer, such as leukemia or lymphoma. Fevers without a clear cause should prompt further investigation.

Persistent, unexplained pain can also indicate cancer. While pain is commonly linked to a wide range of conditions, including non-cancerous issues, a tumor or mass may exert pressure on surrounding tissues, or cancer may spread (metastasize) to other parts of the body, leading to chronic discomfort.

Skin changes may serve as a visual cue for internal health problems. Jaundice, or yellowing of the skin and eyes, can suggest potential liver problems or even cancer. Changes in moles, such as asymmetry, irregular borders, or darkening, should also be assessed by a healthcare professional to rule out skin cancer.

Experts recommend paying close attention to these symptoms, as early detection remains one of the most crucial factors in successfully treating cancer.

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